MSM
Methylsulfonylmethane (MSM) is a sulfur-containing compound found in plants, animals, and humans. It can also be made in a lab into a dietary supplement, which is used widely in alternative medicine. MSM is often used by people looking for a natural way to relieve joint pain, reduce inflammation, and boost immunity.
Many do not realize that MSM is a fantastic Chelator and will help to rid the body of heavy metals along with helping to control the pain and inflammation of arthritis
MSM restores the flexibility and permeability of cell walls, resulting in improved tissue flow conditions. Harmful substances in the form of, for example, lactic acid can be removed from the cells and provided with nutrients, regenerating
MSM can increase the permeability of cell walls, and in doing so your cells have a better chance of absorbing all-important nutrients. MSM also helps reduce inflammation, which can damage skin cells and cause signs of premature aging like wrinkles
MSM is a naturally-occurring compound that some people report can help stimulate hair growth. .
MSM may be beneficial for skin health by acting as a sulfur donor to keratin. This, in turn, can help strengthen this important protein. MSM also helps reduce inflammation, which can damage skin cells and cause signs of premature aging like wrinkles
MSM can benefit all skin types and ages. It is known to have been highly effective in the treatment of conditions including acne, eczema and psoriasis, as well as sensitive, and problematic skin, and helps keep skin healthy and strong to guard against premature ageing and skin damage.
The ability of MSM to mitigate toxin-induced liver damage and support detoxification is due in large part to the sulfur it provides with cysteine availability being the main rate-limiting step in glutathione synthesis not to mention Phase II sulfation activity and the use of the sulfur-containing amino acid taurine..
In 1981 Dr. Herschler was granted a United States utility patent for the use of MSM to smooth and soften skin, to strengthen nails, or as a blood diluent. In addition to the applications laid out in the first Herschler patent, subsequent Herschler patents claimed MSM to relieve stress, relieve pain, treat parasitic infections, increase energy, boost metabolism, enhance circulation, and improve wound healing.
Chronic exposure to stressors can have detrimental effects to the immune system as it becomes desensitized or over-stressed and unable to elicit a typical immune response. The broad effects of IL-6 have been implicated in the maintenance of chronic inflammation [115]. MSM has been shown to reduce IL-6 in vitro, which may mitigate these chronic deleterious effects [86,87,90]. Pre-treatment with MSM, prior to exhaustive exercise, prevented the over-stress of immune cell
MSM modulates the immune response through the crosstalk between oxidative stress and inflammation.
Additionally, MSM may serve other immune modulatory effects related to cell cycle and cell death. In vitro studies indicate that MSM can induce apoptosis in gastrointestinal cancer cells [119], hepatic cancer cells [120], and colon cancer cells [121]. Contrary to these findings, MSM did not induce apoptosis in murine breast cancer cells [122]. Rather, MSM was shown to restore normal cellular metabolism to both metastatic murine breast cancer and murine melanoma cells [123]. Cell cycle arrest has also been observed in gastrointestinal cancer cells [119] and myoblasts [124]. These alterations to cell survival may arise from cyclin production modulations to the p53 and Jak/STAT pathways.
As a therapeutic agent, MSM utilizes its unique penetrability properties to alter physiological effects at the cellular and tissue levels. Furthermore, MSM has the ability to act as a carrier or co-transporter for other therapeutic agents, even furthering its potential applications
Arthritis is an inflammatory condition of the joints that currently affects approximately 58 million adults, with an estimated increase to 78.4 million by 2040 [130]. This inflammation is characterized by pain, stiffness, and a reduced range of motion with regards to the arthritic joint(s). MSM is currently a CAM treatment alone and in combination for arthritis and other inflammatory conditions. MSM, as a micronutrient with enhanced penetrability properties, is commonly integrated with other anti-arthritic agents including glucosamine, chondroitin sulfate, and boswellic acid.
3.2. Cartilage Preservation
Cartilage degradation has long been thought of as the driving force of osteoarthritis [146]. Articular cartilage is characterized by a dense extracellular matrix (ECM) with little to no blood supply driving nutrient extraction from the adjacent synovial fluid [147]. Pro-inflammatory cytokines, particularly IL-1β and TNF-α, are implicated in the destructive process of cartilage ECM [148]. With minimal blood supply and possible hypoxic microenvironments, in vitro studies suggest that MSM protects cartilage through its suppressive effects on IL-1β and TNF-α [86,90,91] and its possibly normalizing hypoxia-driven alterations to cellular metabolism [123].
3.7. Improve Skin Quality and Texture
Since the initial patent awarded to Herschler in 1981, MSM has been suggested to have therapeutic uses for the improvement of skin quality and texture by acting as a sulfur donor to keratin
3.4. To Reduce Muscle Soreness Associated with Exercise
Prolonged strenuous exercise can result in muscle soreness caused by microtrauma to muscles and surrounding connective tissue leading to a local inflammatory response [158]. MSM is alluded to be an effective agent against muscle soreness because of its anti-inflammatory effects as well as its possible sulfur contribution to connective tissue. Endurance exercise-induced muscle damage was reduced with MSM supplementation, as measured by creatine kinase [159]. Pre-treatment with MSM reduced muscle soreness following strenuous resistance exercises [152,160,161] and endurance exercise [162].
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is rich in organic sulphur, an important ‘building block’ for healthy bones and joints, and it’s very useful for your immune system. Available evidence from short-term RCTs shows that MSM may have a moderate effect in improving joint pain and swelling as well as general functional wellbeing in people with osteoarthritis.
MSM is alluded to be an effective agent against muscle soreness because of its anti-inflammatory effects as well as its possible sulfur contribution to connective tissue. Endurance exercise-induced muscle damage was reduced with MSM supplementation, as measured by creatine kinase
Laboratory studies have found that MSM has anti-inflammatory and antioxidant effects. Sulphur, which is a major component of MSM, plays an important role in making collagen and glucosamine, both of which are vital for healthy bones and joints, and in the production of immunoglobulins, which help your immune system.